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Literature summary for 2.5.1.106 extracted from

  • Zhao, W.; Fan, A.; Tarcz, S.; Zhou, K.; Yin, W.B.; Liu, X.Q.; Li, S.M.
    Mutation on Gly115 and Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 increases its catalytic activity toward hydroxynaphthalenes (2017), Appl. Microbiol. Biotechnol., 101, 1989-1998 .
    View publication on PubMed
Search for more literature for 2.5.1.106

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Aspergillus fumigatus

Protein Variants

Protein Variants Comment Organism
G115A significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
G115A/Y205C significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
Y205C significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
Y205F significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
Y205I significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
Y205L significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
Y205M significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus
Y205S significantly increased acceptance of 1-naphthol and other hydroxynaphthalenes by the mutant enzyme Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
brevianamide F + dimethylallyl diphosphate Aspergillus fumigatus
-
 diphosphate + tryprostatin B
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Aspergillus fumigatus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,6-dihydroxynaphthalene + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + 4-(3-methylbut-2-en-1-yl)naphthalene-1,6-diol
-
 ?
1,7-dihydroxynaphthalene + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + 4-(3-methylbut-2-en-1-yl)naphthalene-1,7-diol
-
 ?
1-amino-7-hydroxynaphthalene + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + 8-amino-7-(3-methylbut-2-en-1-yl)naphthalen-2-ol
-
 ?
1-naphthol + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + 4-(3-methylbut-2-en-1-yl)naphthalen-1-ol
-
 ?
2,3-dihydroxynaphthalene + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + ?
-
 ?
2-naphthol + dimethylallyl diphosphate mutants Y205L, Y205M, Y205F, Y205C, Y205I, Y205S, and G115A_Y205C show higher catalytic activities than the non-mutated FtmPT1 Aspergillus fumigatus diphosphate + ?
-
 ?
brevianamide F + dimethylallyl diphosphate
-
 Aspergillus fumigatus diphosphate + tryprostatin B
-
 ?

Synonyms

Synonyms Comment Organism
cyclic dipeptide C2-prenyltransferase FtmPT1
-
 Aspergillus fumigatus

General Information

General Information Comment Organism
metabolism the enzyme is involved in the biosynthesis of a number of biologically active natural products including tryprostatins, spirotryprostatins, verruculogen, and fumitremorgins Aspergillus fumigatus